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Antibiotic Resistance Genes Database at the Center for Bioinformatics and Computational Biology

Address
Center for Bioinformatics and Computational Biology, University of Maryland, College Park, MD, 20742, USA
Type of Facility
Academic
Telephone
n/a
Fax
n/a
Owner
The mission of the ARGD is to provide a centralized compendium of information on antibiotic resistance, facilitate the consistent annotation of resistance information in newly sequenced organisms and facilitate the identification and characterization of new genes.

In order to facilitate identification and characterization of antibiotic resistance genes, we have created a manually curated database (ARDB) unifying most of the publicly available resistance genes and related information. Resistance genes are further categorized to resistance types by their resistance profiles and sequence similarity. Each gene or type is annotated with rich information, including resistance profile, resistance mechanism, resistance requirement, epidemiology, GO term, COG and CDD. ARDB allows the user to browse and search antibiotic resistance information from a view of gene, type, organism and antibiotic. Regular BLAST and RPS-BLAST tools would help the user to identify and annotate new potential resistance genes by blasting against ARDB DNA or protein sequences. ARDB can help user to identify mutational resistance for 12 antibiotic target genes by BLAST. Currently, ARDB contains resistance information for 13293 genes, 377 types, 257 antibiotics, 3369 species and 124 genera.